DExD/H box proteins

DEAD box, DEAH, and the Ski families of proteins are all referred to as DExD/H box proteins.[1] They are all quite distinct from one another and there is not one protein that belongs to more than one of these families. It is thought that each family has a specific role in RNA metabolism, for example both DEAD box and DEAH box proteins NTPase activities become stimulated by RNA, but DEAD box proteins use ATP and DEAH does not.[2]

References

  1. ^ De La Cruz, J.; Kressler, D.; Linder, P. (1999). "Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families". Trends in biochemical sciences 24 (5): 192–198. doi:10.1016/S0968-0004(99)01376-6. PMID 10322435.  edit
  2. ^ Tanner, N.; Cordin, O.; Banroques, J.; Doère, M.; Linder, P. (2003). "The Q motif: A newly identified motif in DEAD box helicases may regulate ATP binding and hydrolysis". Molecular cell 11 (1): 127–138. doi:10.1016/S1097-2765(03)00006-6. PMID 12535527.  edit

See also

Dead box proteins